The game will be a third-person action game, with new combos becoming available to Deadpool as he progresses. The game will be a combination of melee and shooting, with huge emphasis in big hammers, sai, swords and guns. Deadpool will frequently break the fourth wall and verbally interact with the player based on their skill and progress. For instance, in the options menu, he will begin to tap the glass of the television set, before asking, “Hey, got any girls in there?” Deadpool has the opportunity to directly address the player, where he tells them to press a certain button to do certain commands. When presented with the right combination of platforms, he wearily suggests new moves, such as the novel idea of ‘wall jumping’. Deadpool will also show some exaggerated acts of violence, like yelling “No guts no glory” when hanging from his entrails, or shouting “Oh that's gonna leave a mark” when dismembering an enemy.

Combat gameplay relies heavily on using the character’s trademark arsenal of swords and guns, as well as giving players the option to equip more irregular weapons like sledgehammers. By default Deadpool is armed with both guns and swords, but he also has access to giant hammers, laser guns, and a range of other alternatives. Some attacks result in dismemberment or decapitations; body parts and bloodstains can be seen on the ground. There’s a short range teleportation move as well. Since Deadpool possesses an accelerated healing factor, he will slowly fall apart as he sustains damage, and players will be presented with the choice either to reattach severed limbs or wait for them to regrow. Stealth attacks can also be employed, in which close-up camera angles depict more severe damage against enemies.