Skullgirls is a 2D fighting game independently developed by Reverge Labs and co-published by Autumn Games and Konami. The game was released through the PlayStation Network and Xbox Live Arcade in North America, Europe, and Australia from April–May 2012, and later received a Japanese release by CyberFront for the PlayStation Network in February 2013. A Microsoft Windows version, developed by Lab Zero Games and co-published by Autumn Games and Marvelous AQL, was released in August 2013. Skullgirls is also planned to be brought to Japanese arcades in late 2013.

Skullgirls takes place in the fictional Canopy Kingdom, a country "reminiscent of a 1940’s post-war America tinged with magic and intrigue." In a world rife with conflict and dirty dealings, several individuals and organizations seek to obtain the mysterious artifact known as the "Skull Heart". Once every seven years, the Skull Heart grants one young woman's wish. However, if a woman with an impure soul attempts to use the Heart, her wish will be corrupted and she will be transformed into the next Skullgirl, a monstrous entity with immense power. Hundreds have sought after the Skull Heart, but none of its wielders have yet been deemed worthy and spared of its cruel power.

Seven years following the Grand War, a blood-soaked battle fought between three nations, the newest Skullgirl, Marie, has emerged and begun to terrorize the Canopy Kingdom. The game follows several fighters and their journeys to confront Marie and claim the Skull Heart. Each character has her own motive for seeking the Heart, whether to destroy the artifact or use its power for their own interests.