When the MotoGP technical rules changed in the 2002 season, giving priority to four-stroke machinery Ducati decided to enter Grand Prix motorcycle racing.
Ducati's MotoGP motorcycle was unveiled at the 2002 Italian GP at Mugello, for use in the 2003 MotoGP championship. Ducati began taking part in the MotoGP Championship in the 2003 season and won their first championship within 5 years in the 2007 season.

2003
Loris Capirossi and Troy Bayliss competed in all rounds of the 2003 MotoGP championship. Loris Capirossi, got a podium in the opening round of the championship in Japan and won the GP Catalunya in Barcelona. Capirossi finished fourth in the final championship standings and Bayliss sixth; while Ducati finished second overall in the Manufacturers’ standings.

2004
A large part of the 2004 season went by before the bike became competitive, but the season concluded with both riders on the podium.

2005
In the 2005 season, Bayliss was replaced by the Spanish rider Carlos Checa and Ducati switched tyres suppliers to Bridgestone. Capirossi took two wins in the Grand Prix of Japan at Twin Ring Motegi and in the Malaysian GP at Sepang, while Checa scored a brace of podium finishes

2006
Spanish rider Sete Gibernau replaced Checa for the 2006 season. The team took its first win of 2006 in the opening GP at Jerez de la Frontera, followed by a podium in Qatar. Capirossi led the championship for a short while, but at the start of the Grand prix de Catalunya at Barcelona, Capirossi's bike collided with Gibernau's. Both riders ended up injured and in hospital, with Gibernau sustaining a broken collar bone. Capirossi struggled at the Dutch TT race a week later, while Gibernau was replaced by German Alex Hofmann for this race, the British Grand Prix, and also the Czech Grand Prix after undergoing additional surgery. With Gibernau also sidelined for the final round of the season at Valencia, Ducati recalled Bayliss, who was recently crowned Superbike World champion. The race was won by Bayliss, his first MotoGP victory, with Capirossi taking second place for the first Ducati 1-2 finish.

2007
Engine displacement was reduced to 800 cc for the 2007 season. Ducati started development of its 800 cc motorcycle extremely early, and according to Ducati's racing chief Filippo Preziosi, by August 2006, Ducati had already built twenty 800 cc engines with various specifications.[2] Loris Capirossi was joined in the team by Casey Stoner. During the most part of the 2007 season, Stoner dominated the field, obtaining his and the team's first MotoGP World Championship in the circuit of Motegi, Japan, on September 23, 2007, four races before the end of the season.
At the end of season, Ducati's chief engineer Alan Jenkins was awarded the Sir Jackie Stewart Award for brilliance throughout the season.[3]

2008
Casey Stoner remained with the team and was partnered with Marco Melandri from the 2008 Grand Prix motorcycle racing season. Marco had a difficult time adapting to the GP-8's performance. Ducati and Melandri mutually agreed to shorten his two year contract to one year midway through the 2008 MotoGP season.

2009
Again, Casey Stoner remains with the team while Nicky Hayden becomes Stoner's new teammate on the factory Carbon Fibre chassis Ducati GP9, replacing Marco Melandri who moves to Kawasaki for the 2009 Grand Prix motorcycle racing season. Halfway through the season Finnish rookie Mika Kallio has been given the chance to compete for the team in the 11th, 12th and 13th grand prix, due to Stoner being unavailable for those grands prix as he attempts to recover from illness.



2010
Once again Casey Stoner joins with Nicky Hayden for 2010 season

Kebangsaan Australian
Tanggal Lahir 16 October 1985 (umur 24)
Tempat Lahir Southport, QLD (Australia)
No. 27
Juara Dunia 1 (2007)

Casey Stoner (lahir di Kurri-Kurri, New South Wales, Australia, 16 Oktober 1985; umur 24 tahun) adalah seorang pembalap Moto GP. Ia memulai debut balap GP motor sebagai pembalap wild card di sirkuit Donington Park, GP Inggris kelas 125cc pada tahun 2001.

Nicky Hayden (bernama asli Nicholas Patrick Hayden; lahir di Owensboro, Kentucky, Amerika Serikat, 30 Agustus 1981; umur 28 tahun) adalah seorang pembalap MotoGP berkewarganegaraan Amerika Serikat. Ia mulai pindah ke ajang MotoGP pada tahun 2003, setelah sebelumnya menjuarai AMA Superbike (American Motorsport Associaation Superbike) pada tahun 2002. Pada musim pertamanya di MotoGP, pembalap berjuluk “Kentucky kid” ini menjadi rekan satu tim Valentino Rossi di tim Repsol Honda. Di akhir musim kompetisi 2003 ini, ia ada di peringkat ke 5. Pada musim 2004, pembalap yang identik dengan nomor start 69 ini masih bergabung bersama tim yang sama namun dengan partner yang berbeda, ia menjadi rekan satu tim Alex Barros. Di musim 2004 ia berada di peringkat 8 klasemen akhir. Pada musim MotoGP 2005 ia berpartner dengan Max Biaggi di tim Repsol Honda dan prestasinya meningkat menjadi di posisi 3 klasemen akhir. Musim 2006 ia berduet dengan pendatang baru Daniel Pedrosa, masih dalam tim Repsol Honda. Pada musim balap 2006 ini ia berhasil merebut gelar juara dunia dari juara dunia lima kali, Valentino Rossi. Meskipun dengan jumlah juara seri lebih sedikit dari Rossi.

[

11 April\t\tQatar* \t\t\t\tLosail
25 April\t\tJapan \t\t\t\tMotegi
2 May\t\tSpain \t\t\t\tJerez
23 May\t\tFrance \t\t\t\tLe Mans
6 June\t\t Italy \t\t\t\tMugello
20 June\t\tGreat Britain \t\t\tSilverstone
26 June\t\tNetherlands** \t\t\tAssen
4 July\t\tCatalunya \t\t\tCatalunya
18 July\t\tGermany \t\t\tSachsenring
25 July\t\tUnited States*** \t\tLaguna Seca
15 August\tCzech Republic \t\t\tBrno
29 August\tIndianapolis \t\t\tIndianapolis
5 September\tSan Marino & Riviera di Rimini \tMisano
19 September\tHungary \t\t\tBalatonring
10 October\tMalaysia \t\t\tSepang
17 October\tAustralia \t\t\tPhillip Island
31 October\tPortugal \t\t\tEstoril
7 November\tValencia \t\t\tRicardo Tormo Valencia

* Evening Race
** Saturday Race
*** Only MotoGP class